Piers Morgan has led the tributes to Alfie, whose death came after months of legal battles over the 23-month-old’s life support.
Alder Hey Hospital withdrew Alfie’s life support on Monday night after a late night court hearing.
Good Morning Britain host Piers tweeted: “RIP Alfie Evans. My deepest condolences to his parents, who fought so hard for their brave little boy.”
TV Chef James Martin penned: “RIP Alfie Evans”.
British boxer Tony Bellow also sent his condolences.
He wrote: “RIP Alfie Evans… A brave little soldier all the way to the end… Thoughts are with his mother and father today.. #RIPAlfieEvans.”
Former professional boxer Frank Bruno praised Alfie’s parents in his heartfelt message.
He tweeted: “RIP Alfie Evans. Heart breaking news to hear this morning, My thoughts and prayers are with his parents, they did everything they could for this little man. God rest his soul.”
Sky News anchor Kay Burley commented: “RIP Alfie Evans,” beside a picture of the toddler.
Alfie’s parents confirmed the sad loss of their son on Facebook.
Mr Evans wrote: “My gladiator lay down his shield and gained his wings…absolutely heartbroken.”
Alfie had a degenerative neurological condition and was granted Italian citizenship in a bid to transfer him to a hospital in Rome after the case reached the highest levels of Italian government.
Alfie was born back in May 2016, and was first admitted to Alder Hey Hospital in Liverpool the following December.
He had been suffering with seizures and remained as a patient at the hospital ever since.
Following a series of High Court rulings and appeals as medics and parents clashed over the child’s care, judges decided Alfie would not go to Italy earlier this week.
Alfie’s parents applied to the European Court of Human Rights in Strasbourg to take their son to Rome for treatment, but this was also rejected.
Alfie’s life support was switched off on Monday at 9pm, and he died four days later.
In a statement, Alder Hey Children’s Hospital said: “We wish to express our heartfelt sympathy and condolences to Alfie’s family at this extremely distressing time.
“All of us feel deeply for Alfie, Kate, Tom and his whole family and our thoughts are with them.
“This has been a devastating journey for them and we would ask that their privacy and the privacy of staff at Alder Hey is respected.”