The BBC medical drama has worked with mental health charity Mind to put together a special episode which will look at Dr Sacha Levy (played by Bob Barrett) struggling with his emotions.
The long-serving media will be left struggling after a devastating outcome for a favourite patient.
The episode will largely take place on the roof of Holby City Hospital and will let viewers explore previous scenes from a new perspective, as the shattered consultant looks back at a testing year at Holby.
In a first-look clip from the episode, Sacha can be heard insisting that he is not depressed.
He can also be seen debating whether or not he will take his own life. He says: “It would be so simple wouldn’t it to say that’s it, I can’t do this anymore I’m done.”
Speaking about the special instalment, Simon Harper, Executive Producer of Holby City and Casualty, said: “This is an incredibly important episode of Holby where we completely depart from our normal format, focusing on one troubled year in the life of one beloved, vulnerable character.
“Brilliant writer Michelle Lipton shines a light on the vital issue of male mental health and how it can slip under the radar because of the reluctance of many men like Sacha who avoid seeking help for fear of appearing weak.
“Bob’s performance is absolutely heart-breaking and the series producer, Kate Hall, and I are so proud of him. We are also very grateful to Mind and all the support and advice they have given us on this story.”
Meanwhile, Jennie Regan, Mind Media Engagement and Awards Manager, said: “The media has a huge role in shaping public attitudes, educating people and encouraging people to seek support.”
She added that is was “great” to see the BBC series tackle mental health.
“It’s great to see that Holby City is shining a spotlight on the issue of depression and suicide rates in men,” Jennie explained.
She went on to note that she hopes viewers will respond to Sacha’s storyline.
Speaking about Mind’s involvement, she said they support “positive and realistic dramatic depictions of mental health problems”.
“The service works with a large number of dramas and continuing dramas series each week and attempts to include input from people with experience of mental health problems, to help shape scripts and storylines,” Jennie continued.
“If you think you or a loved one might be experiencing a mental health problem then seeking help is one of the most important things you can do. Speak to a friend or family member or go to your GP, who can talk you through the support that’s available or call the Mind Infoline on 0300 123 3393 for more information.”
The instalment will be titled Man Down and was written by Michelle Lipton, produced by Irma Inniss and directed by Tracey Rooney.