A Group of Five team has finally cracked the top four in the College Football Playoff rankings. Cincinnati jumped up to No. 4 in Tuesday’s rankings, giving the Bearcats an opportunity to potentially control their own destiny moving forward. Their first test will come on Friday when they travel to East Carolina during part of the Week 13 college football schedule. Cincinnati is listed as a 14-point favorite in the latest Week 13 college football odds at Caesars Sportsbook.

The Bearcats cannot afford to slip up, as a loss would doom their playoff hopes. Should you trust them to win and cover as two-touchdown favorites? And which other college football lines should you be targeting during rivalry week? Before making any Week 13 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 13 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 13 college football predictions

One of the top college football picks the model is recommending for Week 13: No. 7 Oklahoma State (-3.5) covers against No. 10 Oklahoma in the 2021 Bedlam Series rivalry matchup at 7:30 p.m. ET on Saturday. The Cowboys are normally synonymous with offense, but they boast the top-ranked defense in the Big 12 this season. They’re also putting up 31.4 points per game, and the model sees that combination overwhelming an inconsistent OU squad.

A win in this one and a Big 12 title would be enough to put OSU squarely in the College Football Playoff conversation. The Cowboys have also been a tremendous team to back this season as they’re a sizzling 9-1 against the spread. SportsLine’s model shows them covering more than 60 percent of the time, making OSU a top pick for rivalry week college football bets.

Another one of the college football predictions from the model: No.11  Oregon (-7) takes care of business against Oregon State in a 3:30 p.m. ET matchup on Saturday. The Ducks will be looking to bounce back from a loss to Utah and continue their 18-game home winning streak on Saturday afternoon. They still have plenty to play for, as a win in this game would clinch their spot in the Pac-12 title game. Oregon has won eight of the last 10 meetings in this series, including a 24-10 win at home two years ago.

The Ducks are led by running back Travis Dye, who has rushed for 937 yards and 12 touchdowns on 158 carries. He will be facing an Oregon State run defense that is allowing more than four yards per attempt. SportsLine’s model projects Dye to rush for nearly 90 yards and one touchdown in this game, which is one reason why the Ducks are covering the spread in 60 percent of simulations. 

How to make Week 13 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 13 college football schedule, and it’s also calling for a top College Football Playoff contender to get a huge scare from a big underdog. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdog do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.

Week 13 college football odds (via Caesars)

Here are the college football lines for some of Week 13’s most notable matchups:

Thursday, Nov. 25

Fresno State vs. San Jose State (+7.5, 52.5)

Featured Game | San Jose State Spartans vs. Fresno State Bulldogs

Ole Miss vs. Mississippi State (-1, 60.5)

Featured Game | Mississippi State Bulldogs vs. Ole Miss Rebels

Friday, Nov. 26

Boise State vs. San Diego State (+2.5, 44)

Featured Game | San Diego State Aztecs vs. Boise State Broncos

Iowa vs. Nebraska (-3.5, 44.5)

Featured Game | Nebraska Cornhuskers vs. Iowa Hawkeyes

Missouri vs. Arkansas (-14, 62.5)

Featured Game | Arkansas Razorbacks vs. Missouri Tigers

Cincinnati vs. East Carolina (+14, 58)

Featured Game | East Carolina Pirates vs. Cincinnati Bearcats

Colorado vs. Utah (-24, 52.5)

Featured Game | Utah Utes vs. Colorado Buffaloes

UNC vs. NC State (-7, 63)

Featured Game | NC State Wolfpack vs. North Carolina Tar Heels

Saturday, Nov. 27

Wake Forest vs. Boston College (+5, 64.5)

Featured Game | Boston College Eagles vs. Wake Forest Demon Deacons

Houston vs. UConn (+32.5, 57.5)

Featured Game | Connecticut Huskies vs. Houston Cougars

Georgia vs. Georgia Tech (+35, 54.5)

Ohio State vs. Michigan (+8, 64)

Featured Game | Michigan Wolverines vs. Ohio State Buckeyes

Texas Tech vs. Baylor (-14, 52)

Featured Game | Baylor Bears vs. Texas Tech Red Raiders

UTSA vs. North Texas (+12, 59.5)

Featured Game | North Texas Mean Green vs. UTSA Roadrunners

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